• Introduction Safety critical systems are defined as those sy

  2019-11-12

  

  Introduction Safety-critical systems are defined as those systems where failure could result in the loss of life or injury to people, damage to equipment or to the environment [9]. Safety standards, e.g., [41], [17], [18], [6], [38], expect appropriate safety analysis tasks to be integrated within

• Our results on the acute effects of THC on

  2019-11-12

  

  Our results on the acute effects of THC on resting state kl compound name receptor function are in line with previous neuroimaging findings. Increased perfusion after THC administration in insular and prefrontal regions has previously been reported in smaller samples (Mathew et al., 1997, Mathew et

• Next our exploration shifted to modifications

  2019-11-12

  

  Next, our exploration shifted to modifications at the lateral chain of the benzoquinone nucleus (SAR 2). Considering that the CK2 inhibitory activity is favoured by the presence of the -Ph-4-NO2 (SAR 1), the subsequent analogues were investigated with this moiety retained. The influence of the side

• In a study performed simultaneously by

  2019-11-12

  

  In a study performed simultaneously by another group, EWS-FLI-1 introduction into unsorted murine bone marrow-derived Argatroban australia resulted in tumors with various phenotypes including one that is consistent with that of Ewing sarcoma [68]. The tumors expressed markers associated with Ewing

• br Results br Discussion Fetal

  2019-11-12

  

  Results Discussion Fetal development occurs under conditions of low oxygen tension and steady maternal glucose such that physiologic systems including the pancreas are functionally poised in the prenatal state. Postnatally, oxidative metabolism becomes dominant and intermittent feeding exposes

• Stressful life events are modulators of mood and can

  2019-11-11

  

  Stressful life events are modulators of mood and can trigger a variety of destructive behavior, including drug abuse and relapse in addicts (Association, 2013; Chen et al., 2012; Sinha, 2009). Likewise, drug-associated stimuli evoke a negative affective state in abstinent drug users. Compelling evid

• The ACC receptor family appear to

  2019-11-11

  

  The ACC receptor family appear to be attractive targets for the development of novel anthelmintics. With this in mind we also tested the activity of the anthelmintics levamisole and pyrantel which activate the nematode nAChR (Martin and Robertson, 2007). We found both molecules were partial agonists

• Acknowledgments br Introduction Steroidogenesis the process

  2019-11-11

  

  Acknowledgments Introduction Steroidogenesis, the process of testosterone synthesis, occurs in the adrenal cortex, testis and ovary, and it is controlled by luteinizing hormone (LH), which is synthesized and secreted from the pituitary (Hanukoglu, 1992, Payne and Youngblood, 1995). In the testis

• Consistent with a clear separation of biological

  2019-11-11

  

  Consistent with a clear separation of biological function between ARISC and BRISC in cells, mutations in BRCC36 and Abraxas are prevalent in cancer genomes whereas mutations in KIAA0157 are rare. A survey of the Catalogue of Somatic Mutations in Cancer (COSMIC) consortium, revealed that to date, 37

• The aim of the present study was

  2019-11-11

  

  The aim of the present study was to investigate the participation of CRF1 and CRF2 in the alterations of the dorsal and ventral striatal dopamine release and the vertical and horizontal locomotor activity observed in rats following chronic nicotine treatment and consequent acute withdrawal. In this

• br Cholesterol handling in the arterial wall cells Foam

  2019-11-11

  

  Cholesterol handling in the arterial wall cells Foam cell formation in the arterial intima is a major hallmark of early-stage atherosclerotic lesions, which is attributed to uncontrolled uptake of modified lipoproteins, excess cholesterol esterification and impaired cholesterol release [44]. As a

• An interesting observation pertinent to the immunology

  2019-11-11

  

  An interesting observation pertinent to the immunology of pregnancy comes from a study by Kruse et al., they found that recurrent miscarriage patients with higher serum progesterone levels had lower Th1/Th2 cytokine ratios suggesting that progesterone levels modulate cytokine production patterns. Pr

• By using live imaging of an ERK fluorescence resonance

  2019-11-11

  

  By using live imaging of an ERK fluorescence resonance energy transfer (FRET) sensor, the authors show that ERK activity propagates in a stepwise manner from the center to the periphery of the tracheal placode. This row-by-row propagation of ERK activity fits a relay model in which each row activate

• VMD v Humphrey et al was used to

  2019-11-11

  

  VMD v1.9.2 (Humphrey et al., 1996) was used to analyze the MD trajectories, salt bridge interactions and secondary structure information from each frame. Once the model was optimized, the topological diagram and area and volume of protein cavities were analyzed using PDBsum (Laskowski, 2009) and CAS

• Besides being the only enzyme E is also the largest

  2019-11-11

  

  Besides being the only enzyme, E1 is also the largest and arguably most complex protein encoded by papillomaviruses. As the replicative helicase, E1 plays a central role in the viral life cycle. To do so, E1 engages in multiple protein–protein and protein–nucleic mt t interactions to create a novel

14798 records 872/987 page Previous Next First page 上5页 871872873874875 下5页 Last page