• br Conflicts of interest br Financial support

  2021-04-27

  

  Conflicts of interest Financial support NZ is an Established Investigator of the Dutch Heart Foundation (2013T111) and is supported by an ERC Consolidator grant (617376) from the European Research Council and by a Vici grant from the Netherlands Organization for Scientific Research (NWO; 91818

• Currently two approaches can be used individually or

  2021-04-27

  

  Currently, two approaches can be used individually or combinedly to overcome weak immunogenicity of subunit ap4 (Bookstaver et al., 2018; Moyle, 2017; Vartak and Sucheck, 2016). The first is to design particulate antigens. Virus-like particles (VLPs), for example—mainly derived from the capsid prot

• All components of the UPP were predicted

  2021-04-26

  

  All components of the UPP were predicted to be susceptible to oxidative stress due to the cysteine residues in their active sites [36]. Curcusone D inhibits DUBs but has no significant effect on the action of E1, E2s, E3s, or the proteasome, which indicates that the targets of the ROS induced by cur

• To determine whether the same concentration of humic

  2021-04-26

  

  To determine whether the same concentration of humic Angiotensin I (human, mouse, rat) receptor causes changes in PCR efficiency, we performed another experiment in which the humic acid was added to the PCR mix after bisulfite conversion. All samples that were amplified in the presence of humic acid

• br Experimental procedures br Introduction

  2021-04-26

  

  Experimental procedures Introduction Protein kinases represent one of the largest enzyme 69 0 in the human genome and act as signaling mediators in a variety of cellular processes (Manning et al., 2002). Because many diseases are associated with aberrant protein kinase activity, targeted kina

• Similarly LTD concentration dependently enhanced AQP express

  2021-04-26

  

  Similarly, LTD4 concentration-dependently enhanced AQP4 expression in astrocytes (Fig. 3). The LTD4-enhanced AQP4 expression was not affected by pranlukast but inhibited by Bay u9773, a non-selective CysLT1/CysLT2 receptor antagonist [33]. Because no selective CysLT2 receptor antagonists are current

• Natural and synthetic glucocorticoids perform their biologic

  2021-04-26

  

  Natural and synthetic glucocorticoids perform their biological action in the organism through receptor-dependent mechanisms (e.g., by binding to the glucocorticoid receptors). It has been determined that glucocorticoid receptors cross-talk with other nuclear receptors, including AhR (Celander et al.

• In humans CYP A major isoforms of CYP

  2021-04-26

  

  In humans, CYP3A4/5, major isoforms of CYP3As in the liver, have variants that reduce the enzyme activities [33], [34]. In addition, Werk et al. recently reported the first case of a complete failure of CYP3A enzyme activity due to homozygous loss-of-function mutation of CYP3A4 combined with nonfunc

• RG7388 Among prostaglandins PG PGD remained the

  2021-04-26

  

  Among prostaglandins (PG), PGD2 remained the most elusive species for a long time and was initially regarded as having negligible biological activity [1]. In 1974 its inhibitory effect on platelet aggregation was discovered by Smith et al. [2] and Mills & McFarlain [3], and both pressor and depresso

• br Diseases which have been treated with proteins linked

  2021-04-26

  

  Diseases which have been treated with proteins linked to HSA A number of therapeutic products conjugated to HSA have now been approved for clinical use (Table 2). For example, fatty pyruvate dehydrogenase kinase inhibitor derivatives of human insulin bound to HSA have applications in the treatme

• Among the other mediators which have

  2021-04-26

  

  Among the other mediators which have been reported to play a role in erection are prostaglandins (PGs). Several studies have reported that alprostadil- synthetic PGE1- showed high efficacy in management of erectile dysfunction as it induces corpus cavernosal relaxation. Alprostadil has been first de

• Preliminary studies suggest that dimerization of

  2021-04-26

  

  Preliminary studies suggest that dimerization of the AT1 receptor occurred during the biosynthesis in the endoplasmic reticulum before surface expression [27,40], which may explain the presenece of these TUG 891 before the addition of any ligand. Our results showed that the presence of Ang II did

• The endothelin receptor type B EDNRB

  2021-04-26

  

  The endothelin receptor type B (EDNRB) belongs to the family of G protein-coupled receptors, which functions as a vital regulatory factor in signal transduction in cells, locating on human chromosome 13q22.3 (Ayala-Valdovinos et al., 2016; Bregar et al., 2018; Morimoto et al., 2018; Widowati et al.,

• Some natural products such as curcumin resveratrol and sulfo

  2021-04-25

  

  Some natural products, such as curcumin, resveratrol, and sulforaphane, are known to activate Nrf2 in both in vivo and in vitro experimental models where Nrf2-mediated gene ubiquitin proteasome system plays a crucial protective role [8]. Under basal conditions, Nrf2 binds to Kelch-like ECH-associat

• Because EBI is expressed on

  2021-04-25

  

  Because EBI2 is expressed on the major subsets of immune cells, and small molecule antagonists for EBI2 were recently described (Benned-Jensen et al., 2013, Gessier et al., 2014), EBI2 constitutes a tempting drug target reminiscent of the sphingosine-1-phosphate receptor superagonist fingolimod/Gile

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